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Scaffold‐Free Bioprinting: Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold‐Free Tissue Strands as Building Blocks (Adv. Healthcare Mater. 22/2020)
Author(s) -
Wu Yang,
Ayan Bugra,
Moncal Kazim K.,
Kang Youngnam,
Dhawan Aman,
Koduru Srinivas V.,
Ravnic Dino J.,
Kamal Fadia,
Ozbolat Ibrahim T.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070081
Subject(s) - scaffold , 3d bioprinting , cartilage , materials science , biomedical engineering , articular cartilage , tissue engineering , matrix (chemical analysis) , anatomy , medicine , composite material , pathology , osteoarthritis , alternative medicine
Using a novel hybrid approach integrating aspiration‐assisted bioprinting and extrusion‐based bioprinting, a zonally stratified cartilage is fabricated, in which collagen fibers are aligned with designated orientation in each zone imitating the anatomical regions and matrix orientation of native cartilage tissue. These findings, in article number 2001657 by Ibrahim T. Ozbolat and co‐workers, highlight the potential of this approach for building biologically, mechanically, and histologically relevant cartilage for tissue engineering purposes.