Premium
Carbon Nanotubes: Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer (Adv. Healthcare Mater. 21/2020)
Author(s) -
Chen Wen,
Yang Sainan,
Wei Xia,
Yang Zailin,
Liu Dongxu,
Pu Xin,
He Silian,
Zhang Yong
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070080
Subject(s) - chimera (genetics) , aptamer , dicer , carbon nanotube , membrane , cancer cell , targeted drug delivery , cancer research , small interfering rna , drug delivery , nanotechnology , cancer , materials science , rna , microbiology and biotechnology , medicine , chemistry , biology , gene , biochemistry
In article number 2001153 by Yong Zhang and co‐workers, aptamer‐siRNA Chimera/PEI/5‐FU/carbon nanotube (CNT)/collagen membranes are constructed to treat peritoneal dissemination of drug‐resistant gastric cancer. Chimeras can specifically bind to gastric cancer cells, then 5‐FU and chimeras are released. Chimeras are cut into siRNA by Dicer, which mediates targeted mRNA degradation.