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MOF Drug Carriers: Biodegradable Metal–Organic Framework‐Based Microrobots (MOFBOTs) (Adv. Healthcare Mater. 20/2020)
Author(s) -
Terzopoulou Anastasia,
Wang Xiaopu,
Chen XiangZhong,
PalaciosCorella Mario,
Pujante Carlos,
HerreroMartín Javier,
Qin XiaoHua,
Sort Jordi,
deMello Andrew J.,
Nelson Bradley J.,
PuigmartíLuis Josep,
Pané Salvador
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070076
Subject(s) - materials science , gelatin , drug delivery , biodegradable polymer , nanotechnology , metal organic framework , drug , composite number , polymer , biomedical engineering , chemistry , composite material , pharmacology , organic chemistry , engineering , medicine , adsorption
In article number 2001031 by Xiang‐Zhong Chen, Josep Puigmartí‐Luis, and co‐workers, highly integrated MOFBOTs are developed for targeted drug delivery. Fe@ZIF‐8, a magnetic MOF composite synthesized via a one‐pot procedure, plays a dual role of drug carrier and motile component of the microrobot. pH‐triggered degradation of the MOF and enzymatic degradation of the gelatin‐based chassis result in an overall degradable system, which opens new avenues for highly integrated fully biodegradable small‐scale robots.