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Gold Nanoparticles: Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance (Adv. Healthcare Mater. 20/2020)
Author(s) -
Valle Andrea C.,
Yeh ChihKuang,
Huang YuFen
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070074
Subject(s) - photothermal therapy , cancer cell , drug , drug delivery , materials science , intracellular , platinum , nanotechnology , cancer , colloidal gold , programmed cell death , cancer research , chemistry , nanoparticle , medicine , pharmacology , biochemistry , apoptosis , catalysis
In article number 2000864 by Yu‐Fen Huang and co‐workers, platinum‐decorated gold nanostars (Pt‐AuNS) are presented as a novel metal nanoprodrug for combined photothermal‐ferroptotic therapy to combat cancer drug resistance. Upon NIR irradiation, the active metallic (Pt and Au) payloads are released, inducing selective cancer cell death. The mechanism of action is attributed to the intracellular GSH depletion and GPX4 inactivation, leading to a subsequent accumulation of lipid hydroperoxides that executes ferroptosis.