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Tissue Engineering: In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications (Adv. Healthcare Mater. 19/2020)
Author(s) -
Flegeau Killian,
Toquet Claire,
Rethore Gildas,
d'Arros Cyril,
Messager Léa,
Halgand Boris,
Dupont Davy,
Autrusseau Florent,
Lesoeur Julie,
Veziers Joëlle,
Bordat Pascal,
Bresin Anthony,
Guicheux Jérôme,
Delplace Vianney,
Gautier Hélène,
Weiss Pierre
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070068
Subject(s) - hyaluronic acid , self healing hydrogels , tissue engineering , in situ , materials science , in vivo , biomedical engineering , chemical engineering , nanotechnology , chemistry , polymer chemistry , organic chemistry , anatomy , medicine , microbiology and biotechnology , biology , engineering
In article number 2000981 by Pierre Weiss and co‐workers, an in situ forming, single‐component hyaluronic acid hydrogel is reported based on the pH‐triggered condensation of silanols into siloxanes. In vitro, cytocompatible hydrogels with tunable mechanical properties are obtained by tuning the crosslink density. In vivo, the hydrogel's degradability can be adapted, while elicitating minimum inflammation. Silanized hyaluronic gels are potent minimally invasive vehicles for tissue engineering.