Microfluidics: Enhancing the Injectability of High Concentration Drug Formulations Using Core Annular Flows (Adv. Healthcare Mater. 18/2020) | Zendy

Jayaprakash Vishnu | Zendy; Costalonga Maxime | Zendy; Dhulipala Somayajulu | Zendy; Varanasi Kripa K. | Zendy

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Microfluidics: Enhancing the Injectability of High Concentration Drug Formulations Using Core Annular Flows (Adv. Healthcare Mater. 18/2020)

Author(s) -

Jayaprakash Vishnu,

Costalonga Maxime,

Dhulipala Somayajulu,

Varanasi Kripa K.

Publication year - 2020

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.202070066

Subject(s) - viscosity , materials science , microfluidics , syringe , core (optical fiber) , viscous liquid , drug delivery , biomedical engineering , nanotechnology , mechanics , composite material , mechanical engineering , medicine , physics , engineering

In article number 2001022 by Kripa K. Varanasi and co‐workers, a new methodology to inject highly viscous drug formulations subcutaneously using core annular flows is developed. In such a flow, the viscous formulation is lubricated axially by a less viscous fluid. A 7x reduction in injection force is achieved for the highest viscosity ratio tested. As a practical embodiment, a proof‐of‐concept double barrel syringe is fabricated, expanding the range of injectable viscosities considerably compared to conventional syringes without a significant increase in price.

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