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Microfluidics: Enhancing the Injectability of High Concentration Drug Formulations Using Core Annular Flows (Adv. Healthcare Mater. 18/2020)
Author(s) -
Jayaprakash Vishnu,
Costalonga Maxime,
Dhulipala Somayajulu,
Varanasi Kripa K.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070066
Subject(s) - viscosity , materials science , microfluidics , syringe , core (optical fiber) , viscous liquid , drug delivery , biomedical engineering , nanotechnology , mechanics , composite material , mechanical engineering , medicine , physics , engineering
In article number 2001022 by Kripa K. Varanasi and co‐workers, a new methodology to inject highly viscous drug formulations subcutaneously using core annular flows is developed. In such a flow, the viscous formulation is lubricated axially by a less viscous fluid. A 7x reduction in injection force is achieved for the highest viscosity ratio tested. As a practical embodiment, a proof‐of‐concept double barrel syringe is fabricated, expanding the range of injectable viscosities considerably compared to conventional syringes without a significant increase in price.