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Biodegradable Films: Microporous Biodegradable Films Promote Therapeutic Angiogenesis (Adv. Healthcare Mater. 17/2020)
Author(s) -
Hendow Eseelle K.,
Moazen Mehran,
Iacoviello Francesco,
Bozec Laurent,
PelletMany Caroline,
Day Richard M.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070059
Subject(s) - angiogenesis , microporous material , therapeutic angiogenesis , neovascularization , materials science , in vivo , biomedical engineering , nanotechnology , cancer research , medicine , composite material , biology , microbiology and biotechnology
In article number 2000806 by Richard M. Day and co‐workers, highly porous biodegradable films are prepared using thermally‐induced phase separation. In vivo implantation of the films into ischemic tissue stimulates increased expression of pro‐angiogenic growth factor genes. This provides a favourable local environment for neovascularization, increased tissue perfusion, and therapeutic angiogenesis in ischemic tissue. The findings pave the way to establishing new materials‐based strategies to achieve therapeutic angiogenesis.