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Acute Cardiac Rejection: Antagomir‐155 Attenuates Acute Cardiac Rejection Using Ultrasound Targeted Microbubbles Destruction (Adv. Healthcare Mater. 14/2020)
Author(s) -
Yi Luyang,
Chen Yihan,
Jin Qiaofeng,
Deng Cheng,
Wu Ya,
Li Huiling,
Liu Tianshu,
Li Yuman,
Yang Yali,
Wang Jing,
Lv Qing,
Zhang Li,
Xie Mingxing
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070046
Subject(s) - sonoporation , microbubbles , antagomir , medicine , ultrasound , cardiology , microrna , radiology , chemistry , biochemistry , gene
In article number 2000189 by Li Zhang, Mingxing Xie, and co‐workers, cationic microbubbles composed of DOTAP, DSPC, and DSPE‐PEG2000 are synthesized to carry antagomir‐155 and deliver it to allograft heart in a murine model by ultrasound targeted microbubbles destruction (UTMD). Sonoporation and cavitation make antagomir‐155 penetrate vascular endothelium into intracellular region of allograft heart. This therapy downregulates microRNA‐155 level in graft heart and attenuates degree of acute cardiac rejection.