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Injectable Hydrogels: Microskin‐Inspired Injectable MSC‐Laden Hydrogels for Scarless Wound Healing with Hair Follicles (Adv. Healthcare Mater. 10/2020)
Author(s) -
Zheng Xin,
Ding Zhaozhao,
Cheng Weinan,
Lu Qiang,
Kong Xiangdong,
Zhou Xiaozhong,
Lu Guozhong,
Kaplan David L.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070029
Subject(s) - self healing hydrogels , mesenchymal stem cell , nanofiber , wound healing , paracrine signalling , regeneration (biology) , angiogenesis , biomedical engineering , materials science , medicine , microbiology and biotechnology , nanotechnology , surgery , cancer research , pathology , polymer chemistry , biology , receptor
In article number 2000041 by Qiang Lu, Xiaozhong Zhou, Guozhong Lu, and co‐workers, microgels composed of aligned silk nanofibers are used to load mesenchymal stem cells (MSCs) to actively modulate the paracrine. The MSCs‐laden microgels are blended with injectable silk nanofiber hydrogels to accelerate the wound healing. The synergistic action of MSCs‐laden hydrogel systems stimulates angiogenesis and M1‐M2 phenotype switching of macrophages, achieving scarless skin regeneration with hair follicles.