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Neural Regeneration: A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles (Adv. Healthcare Mater. 6/2020)
Author(s) -
Sun Ying,
Duan Bingchao,
Chen Huanhuan,
Xu Xiaojuan
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070018
Subject(s) - inflammatory bowel disease , methotrexate , colitis , medicine , cytotoxicity , regeneration (biology) , inflammation , glucan , disease , pharmacology , immunology , chemistry , biology , biochemistry , in vitro , microbiology and biotechnology
In article number 1901805 by Xiaojuan Xu and co‐workers, a targeted oral delivery system is constructed by loading methotrexate (MTX) into yeast glucan particles (YGPs) for inflammatory bowel disease therapy, which can be internalized into macrophages efficiently. Furthermore, YGPs accumulate in the inflammation site of colitis mice, enabling YGPs/MTX to target the inflammatory site, significantly improve the efficacy of MTX, and reduce the cytotoxicity of MTX.