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Bone Replacement: The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material (Adv. Healthcare Mater. 2/2020)
Author(s) -
Quade Mandy,
Münch Pina,
Lode Anja,
Duin Sarah,
Vater Corina,
Gabrielyan Anastasia,
RösenWolff Angela,
Gelinsky Michael
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202070005
Subject(s) - angiogenesis , chemotaxis , bone healing , biomedical engineering , hypoxia (environmental) , microbiology and biotechnology , materials science , chemistry , medicine , cancer research , biology , anatomy , biochemistry , receptor , organic chemistry , oxygen
In article number 1901426 by Anja Lode and co‐workers, sustained release of hypoxia‐conditioned MSC secretome from a central depot induces directed hBMSC migration and angiogenesis in biomimetic mineralized collagen scaffolds. This in situ tissue engineering concept is suggested to be a cell‐free and ready‐to‐use therapeutic solution for accelerated bone defect healing.