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Advanced Human BBB‐on‐a‐Chip: A New Platform for Alzheimer's Disease Studies
Author(s) -
Yoon JeongKee,
Kim Jaehoon,
Shah Zachary,
Awasthi Ashi,
Mahajan Advay,
Kim YongTae
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202002285
Subject(s) - neuroscience , blood–brain barrier , drug development , disease , human brain , human disease , medicine , drug , biology , pharmacology , central nervous system , pathology
The blood−brain barrier (BBB) is a unique vascular structure that serves as a molecular transport gateway for the maintenance of brain homeostasis. Chronic disruption or breakdown of the BBB reportedly leads to neurodegenerative diseases. Nonetheless, research on human BBB pathophysiology and drug development remains highly dependent on studies using inherently different animals. Moreover, more studies have shown that animal models are not appropriate in modeling Alzheimer's disease (AD), underlining the importance of in vitro models of the human BBB with physiological relevance. In this review, recent advances in human BBB‐on‐a‐chip technologies are highlighted and their potential for pathogenesis studies and drug prescreening for AD treatment are discussed.