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Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing
Author(s) -
Samandari Mohamadmahdi,
Aghabaglou Fariba,
Nuutila Kristo,
Derakhshandeh Hossein,
Zhang Yuteng,
Endo Yori,
Harris Seth,
Barnum Lindsay,
KreikemeierBower Craig,
ArabTehrany Elmira,
Peppas Nicholas A.,
Sinha Indranil,
Tamayol Ali
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202001800
Subject(s) - wound healing , drug delivery , angiogenesis , medicine , pharmacology , in vivo , biomedical engineering , vascular endothelial growth factor , drug , vegf receptors , surgery , cancer research , materials science , nanotechnology , biology , microbiology and biotechnology
A major impediment preventing normal wound healing is insufficient vascularization, which causes hypoxia, poor metabolic support, and dysregulated physiological responses to injury. To combat this, the delivery of angiogenic factors, such as vascular endothelial growth factor (VEGF), has been shown to provide modest improvement in wound healing. Here, the importance of specialty delivery systems is explored in controlling wound bed drug distribution and consequently improving healing rate and quality. Two intradermal drug delivery systems, miniaturized needle arrays (MNAs) and liquid jet injectors (LJIs), are evaluated to compare effective VEGF delivery into the wound bed. The administered drug's penetration depth and distribution in tissue are significantly different between the two technologies. These systems' capability for efficient drug delivery is first confirmed in vitro and then assessed in vivo. While topical administration of VEGF shows limited effectiveness, intradermal delivery of VEGF in a diabetic murine model accelerates wound healing. To evaluate the translational feasibility of the strategy, the benefits of VEGF delivery using MNAs are assessed in a porcine model. The results demonstrate enhanced angiogenesis, reduced wound contraction, and increased regeneration. These findings show the importance of both therapeutics and delivery strategy in wound healing.