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Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery Strategies
Author(s) -
Chang Calvin,
Yan Jerry,
Yao Zhicheng,
Zhang Chi,
Li Xiaowei,
Mao HaiQuan
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202001689
Subject(s) - mesenchymal stem cell , paracrine signalling , microbiology and biotechnology , stem cell , angiogenesis , extracellular vesicles , cell , regeneration (biology) , biology , cancer research , receptor , biochemistry
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.