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Recent Advances in Antiinflammatory Material Design
Author(s) -
Lebaudy Eloïse,
Fournel Sylvie,
Lavalle Philippe,
Vraihal Engin,
Gribova Varvara
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202001373
Subject(s) - regeneration (biology) , self healing hydrogels , drug delivery , inflammation , nanotechnology , inflammatory response , coating , angiogenesis , computer science , materials science , medicine , biology , immunology , cancer research , microbiology and biotechnology , polymer chemistry
Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.