Premium
Temperature Feedback‐Controlled Photothermal/Photodynamic/Chemodynamic Combination Cancer Therapy Based on NaGdF 4 :Er,Yb@NaGdF 4 :Nd@Cu‐BIF Nanoassemblies
Author(s) -
Qi Ye,
Ye Junwei,
Ren Shuangsong,
Wang Guangyao,
Lv Jialin,
Zhang Siqi,
Che Ying,
Li Yachen,
Chen Baojiu,
Ning Guiling
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202001205
Subject(s) - photothermal therapy , photodynamic therapy , materials science , in vivo , fluorescence , nanotechnology , chemistry , optics , physics , microbiology and biotechnology , organic chemistry , biology
The intelligent design of multifunctional nanoplatforms is critical for cancer therapy. Herein, NaGdF 4 :Er,Yb@NaGdF 4 :Nd@Cu(II) boron−imidazolate frameworks (denoted as CSNPs@Cu‐BIF) nanoassemblies are designed and fabricated. Upon a single 808 nm laser irradiation, the nanoassemblies not only show the outstanding photothermal conversion capacity ( η = 41.7%) but also generate cytotoxic reactive oxygen species through an in situ Fenton‐like reaction and fluorescence resonance energy transfer. Importantly, the nanoassemblies simultaneously introduce remarkable antitumor efficacy via photothermal/photodynamic/chemodynamic combination therapy both in vitro and in vivo. To improve the therapeutic effect of solid tumor ablation, it is highly desirable to monitor the treatment process in real‐time. Multiclinical imaging modalities of ultrasonography are employed to systematically investigate the ablation mechanism of solid tumors in vivo. Furthermore, the significant difference between the eigen temperature of CSNPs@Cu‐BIF nanoassemblies obtained by the temperature‐sensitive emission bands signal changes and the apparent temperature recorded by the thermal imaging camera is 14.55 K at equilibrium. This current work therefore supplies an alternative strategy in temperature feedback‐controlled accurate cancer therapy.