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Ultrastable Near‐Infrared Nonlinear Organic Chromophore Nanoparticles with Intramolecular Charge Transfer for Dually Photoinduced Tumor Ablation
Author(s) -
Zhang Yi,
Shi Mengke,
Yan Zhangren,
Zhang Shao,
Wang Mengya,
Xu Han,
Li Hongyu,
Ying Yuchen,
Qiu Shihong,
Liu Jialei,
Yang Hong,
Chen Huabing,
He Hui,
Guo Zhengqing
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202001042
Subject(s) - singlet oxygen , photothermal therapy , photodynamic therapy , nanoparticle , photochemistry , chromophore , materials science , photosensitizer , tumor ablation , photoinduced electron transfer , phototoxicity , ablation , chemistry , nanotechnology , electron transfer , oxygen , organic chemistry , in vitro , biochemistry , aerospace engineering , engineering
Near‐infrared (NIR) light‐responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS nanoparticles with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear organic chromophore nanoparticles (NOC‐NPs) are shown as single‐component PS for dually cooperative phototherapy. Upon 785 nm irradiation, excited NOC‐NPs pass through intrinsic intramolecular charge transfer (ICT) channel to generate both abundant singlet oxygen and local hyperthermia, affording synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor ablation. Furthermore, NOC‐NPs exhibit dramatic photostability, enhanced cellular uptake, effective cytoplasmic translocation, as well as preferable tumor accumulation, further ensuring favorable in vivo singlet oxygen generation and hyperthermia for photoinduced tumor ablation. Thus, NOC‐NPs may represent novel high‐performance PS for synergistic photoinduced cancer therapy, providing new insights into the development of potent PS for clinical translation.