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A pH‐Sensitive Self‐Assembled and Carrier‐Free Nanoparticle Based on Charge Reversal for Enhanced Synergetic Chemo‐Phototherapy
Author(s) -
Liu Chen,
Liu Qiuhong,
Chen Luping,
Li Mao,
Yin Jieli,
Zhu Xuan,
Chen Dengyue
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000899
Subject(s) - nanoparticle , drug delivery , materials science , surface charge , stacking , fluorescence lifetime imaging microscopy , nanotechnology , fluorescence , combinatorial chemistry , chemistry , organic chemistry , physics , quantum mechanics
To overcome biological barriers for nanoparticles (NPs) efficaciously accumulated at tumor sites, as well as enhancing the performance of drug delivery systems, a carrier‐free nanoparticle based on charge reversal is designed for improved synergetic chemo‐phototherapy for cancer treatment. In this system, doxorubicin (Dox) and zinc phthalocyanine (ZnPc) are self‐assembled through noncovalent interactions (π–π stacking, hydrophobic forces) to avoid the possible toxicity of excipient, complex chemical conjugations and batch‐to‐batch variation. A trace amount of poly(2‐(di‐methylamino) ethylmethacrylate)‐ poly[(R)‐3‐hydroxybutyrate]‐ poly(2‐(dimethylamino) ethylmethacrylate (PDMAEMA‐PHB‐PDMAEMA) is modified on the surface of Dox–ZnPc to construct the novel nanoparticles, namely DZP, with long‐term stability, and with a dual‐drug load content of up to ≈90. The drug delivery system (DDS) can effectively decrease its toxicity among physical circulation and increase the accumulation at the tumor site. Moreover, the developed DZP nanoparticles show excellent photo‐chemotherapy, photoacoustic (PA) and fluorescence (FL) imaging characteristics for multimodal imaging‐guided synergetic therapy.