Premium
Bacteria‐Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications
Author(s) -
Liu Lin,
Wu Jiahe,
Gao Jianqing,
Lu Xiaoyang
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000893
Subject(s) - bacteria , nanotechnology , flexibility (engineering) , biomaterial , surface modification , nanoparticle , materials science , biochemical engineering , biology , engineering , chemical engineering , statistics , genetics , mathematics
In recent decades, investigations on bacteria‐derived materials have progressed from being a proof of concept to a means for improving traditional biomaterials. Owing to their unique characteristics, such as gene manipulation, rapid proliferation, and specific targeting, bacteria‐derived materials have provided remarkable flexibility in applied biomedical functionalization. In this review, bacteria‐derived nanoparticles are focused on as a promising biomaterial, introducing several bacterial species with great potential and useful strategies for fabrication. Through well‐designed choices, bacteria‐derived nanoparticles can be exploited to obtain functional bacteria‐mimicking materials for a variety of applications, including cargo delivery, imaging, therapy, and immune modulation. Finally, the prospects and challenges of bacteria‐derived nanoparticles are discussed. Particularly, safety concerns regarding the use of bacteria and their immunogenicity remain major obstacles to the clinical application of bacteria‐derived nanoparticles and these concerns are immediate priorities for the research community.