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Microporous Biodegradable Films Promote Therapeutic Angiogenesis
Author(s) -
Hendow Eseelle K.,
Moazen Mehran,
Iacoviello Francesco,
Bozec Laurent,
PelletMany Caroline,
Day Richard M.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000806
Subject(s) - therapeutic angiogenesis , angiogenesis , in vivo , blood flow , ischemia , perfusion , neovascularization , microporous material , biomedical engineering , medicine , blood vessel , pharmacology , materials science , cardiology , cancer research , biology , microbiology and biotechnology , composite material
Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material‐based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material‐based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo.