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Review of Integrin‐Targeting Biomaterials in Tissue Engineering
Author(s) -
Dhavalikar Prachi,
Robinson Andrew,
Lan Ziyang,
Jenkins Dana,
Chwatko Malgorzata,
Salhadar Karim,
Jose Anupriya,
Kar Ronit,
Shoga Erik,
Kannapiran Aparajith,
CosgriffHernandez Elizabeth
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000795
Subject(s) - regeneration (biology) , biomaterial , tissue engineering , extracellular matrix , integrin , microbiology and biotechnology , mesenchymal stem cell , angiogenesis , wound healing , chemistry , cell , biomedical engineering , materials science , nanotechnology , biology , medicine , immunology , cancer research , biochemistry
The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix‐derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin‐targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin‐mediated cellular processes that have been identified in angiogenesis, wound healing, and bone regeneration. Then, research utilizing biomaterials are highlighted with integrin‐targeting motifs as a means to direct these cellular processes to enhance tissue regeneration. In addition to providing improved materials for tissue repair and device integration, these innovative biomaterials provide new tools to probe the complex processes of tissue remodeling in order to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.