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Human Oral Motion‐Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo‐biomodulation Therapy
Author(s) -
Park Moonchul,
Islam Sayemul,
Kim HyeEun,
Korostoff Jonathan,
Blatz Markus B.,
Hwang Geelsu,
Kim Albert
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000658
Subject(s) - dental implant , medicine , implant , dentistry , osseointegration , soft tissue , biomedical engineering , surgery
Peri‐implant disease is an inflammatory condition affecting the soft and hard tissues surrounding a dental implant. However, current preventative methods are insufficient due to the limited bioactivity on the dental implant and poor patient compliance. Recently, photo‐biomodulation (PBM) therapy that can recover and regenerate peri‐implant soft tissue has attracted considerable attention in dentistry. In this paper, a seamless human oral motion‐powered dental implant system (called Smart Dental Implant or SDI) is presented as an ambulatory PBM therapy modality. SDI allows the in situ light delivery, which is enabled by the energy harvesting from dynamic human oral motions (chewing and brushing) via an engineered piezoelectric dental crown, an associated circuit, and micro light emitting diodes (LEDs). The SDI also offers adequate mechanical strength as the clinical standards. Using primary human gingival keratinocytes (HGKs) as a model host organism and Pseudomonas aeruginosa lipopolysaccharides (LPS) as a model inflammatory stimulus, effective SDI‐mediated PBM therapy is demonstrated. A new class of dental implants could be an ambulatory PBM therapy platform for the prevention of peri‐implant disease without patient dependency, warranting long‐lasting dental implants.