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Nucleolus‐Targeted Photodynamic Anticancer Therapy Using Renal‐Clearable Carbon Dots
Author(s) -
Pang Wen,
Jiang Pengfei,
Ding Shihui,
Bao Zhouzhou,
Wang Ningtao,
Wang Hongxia,
Qu Junle,
Wang Dan,
Gu Bobo,
Wei Xunbin
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202000607
Subject(s) - photodynamic therapy , in vivo , biocompatibility , photosensitizer , quantum dot , nanotechnology , materials science , nanobiotechnology , reactive oxygen species , nucleolus , biophysics , cancer research , chemistry , nanoparticle , medicine , photochemistry , biology , biochemistry , organic chemistry , microbiology and biotechnology , cytoplasm , metallurgy
Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub‐cellular organelles, but most PSs cannot target nucleolus, which is demonstrated as a more efficient and ideal site for cancer treatment. Here, an effective carbon dots (C‐dots) photosensitizer with intrinsic nucleolus‐targeting capability, for the first time, is synthesized, characterized, and employed for in vitro and in vivo image‐guided photodynamic anticancer therapy with enhanced treatment performance at a low dose of PS and light irradiation. The C‐dots possess high ROS generation efficiency and fluorescence quantum yield, excellent in vitro and in vivo biocompatibility, and rapid renal clearance, endowing it with a great potential for future translational research.