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Dissolving Microneedles: Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate (Adv. Healthcare Mater. 21/2019)
Author(s) -
Hou Ailin,
Quan Guilan,
Yang Beibei,
Lu Chao,
Chen Minglong,
Yang Dan,
Wang Lili,
Liu Hu,
Pan Xin,
Wu Chuanbin
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970083
Subject(s) - dissolution , materials science , drug delivery , polymer , biomedical engineering , nanotechnology , chemical engineering , composite material , medicine , engineering
In article number 1900898 by Xin Pan, Chuanbin Wu, and co‐workers, a rapidly separating dissolving microneedles (RSDMNs) system is constructed to achieve controlled and precise drug delivery. The polymer‐sugar complex is used to constitute the separating part with high disintegration rate as well as sufficient mechanical performance. After administration, the blank separating part rapidly disintegrates and detaches from the base and embeds the drug‐concentrated tips into the skin. Both the ex vivo and in vivo results confirm the superiority of RSDMNs as compared with traditional dissolving microneedles.