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Hematopoietic Stem Cells: Soluble Signals and Remodeling in a Synthetic Gelatin‐Based Hematopoietic Stem Cell Niche (Adv. Healthcare Mater. 20/2019)
Author(s) -
Gilchrist Aidan E.,
Lee Sunho,
Hu Yuhang,
Harley Brendan A. C.
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970080
Subject(s) - stem cell , haematopoiesis , mesenchymal stem cell , microbiology and biotechnology , paracrine signalling , gelatin , hematopoietic stem cell , self healing hydrogels , niche , materials science , biology , biochemistry , receptor , polymer chemistry
In article number 1900751 by Brendan A. C. Harley and co‐workers, a library of gelatin hydrogels with well‐defined biophysical and biotransport properties are used as an artificial hematopoietic stem cell (HSC) niche. This work explores the role of matrix remodeling and paracrine signals generated by co‐cultured mesenchymal stem cells on HSC proliferation and quiescence.