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Tissue Engineering: Self‐Assembling Peptide Hydrogel Matrices Improve the Neurotrophic Potential of Human Adipose‐Derived Stem Cells (Adv. Healthcare Mater. 17/2019)
Author(s) -
Faroni Alessandro,
Workman Victoria L.,
Saiani Alberto,
Reid Adam J.
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970073
Subject(s) - adipose tissue , downregulation and upregulation , stem cell , neurotrophic factors , tissue engineering , phenotype , neurotrophin , microbiology and biotechnology , materials science , chemistry , gene , biomedical engineering , biology , medicine , biochemistry , receptor
In article number 1900410 by Alessandro Faroni and co‐workers, human adipose‐derived stem cells (hASC) can be differentiated toward a neurotrophic phenotype (hdASC) by chemical stimulation. The differentiation causes up/downregulation of key neuroglial genes. In this study, hdASC are plated with PeptiGel‐Alpha1 and Alpha2 substrates, as well as Col I, and the expression levels of differentiation genes is assessed.