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Antibiotic Delivery: In Vitro and In Vivo Antimicrobial Activity of Antibiotic‐Conjugated Carriers with Rapid pH‐Responsive Release Kinetics (Adv. Healthcare Mater. 14/2019)
Author(s) -
Kang Sunyoung,
Park Gee Ho,
Kim Seulah,
Kim Jungah,
Choi Yoonhwa,
Huang Yan,
Lee Yan,
Choi Tae Hyun
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970058
Subject(s) - antibiotics , antimicrobial , in vivo , conjugate , drug delivery , in vitro , microbiology and biotechnology , chemistry , pharmacology , medicine , biochemistry , biology , organic chemistry , mathematical analysis , mathematics
In article number 1900247 by Yan Lee, Tae Hyun Choi, and co‐workers, a pH‐responsive antibiotic drug conjugate system is developed using a maleic acid amide‐based linker. The conjugate system can rapidly release the antibiotics and induce antimicrobial activities against S. aureus at weakly acidic environments in abscesses or inflammatory tissues.