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Pluripotent Stem Cell Heterogeneity: Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation (Adv. Healthcare Mater. 13/2019)
Author(s) -
Yu Leqian,
Li Junjun,
Minami Itsunari,
Qu Xiang,
Miyagawa Shigeru,
Fujimoto Nanae,
Hasegawa Kouichi,
Chen Yong,
Sawa Yoshiki,
Kotera Hidetoshi,
Liu Li
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970053
Subject(s) - induced pluripotent stem cell , human induced pluripotent stem cells , microbiology and biotechnology , stem cell , cellular differentiation , biology , cell type , cell , embryonic stem cell , genetics , gene
In article number 1900165 by Li Liu and co‐workers, a nanofibrous platform is used for investigating heterogeneity among single pluripotent stem cells. One type of subclone is established and found to have distinct morphology and its cardiac derivatives show higher differentiation efficiency, increased maturation, and stronger beating compared to those derived from the other subclones. This selection process also holds potential for improving differentiation efficiency toward other cell types.