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Insulin Delivery: Supercritical Fluid‐Assisted Porous Microspheres for Efficient Delivery of Insulin and Inhalation Therapy of Diabetes (Adv. Healthcare Mater. 12/2019)
Author(s) -
Lin XiaoFen,
Kankala Ranjith Kumar,
Tang Na,
Xu PeiYao,
Hao LiuZhi,
Yang DaYun,
Wang ShiBin,
Zhang Yu Shrike,
Chen AiZheng
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970048
Subject(s) - inhalation , insulin , microsphere , supercritical fluid , diabetes mellitus , medicine , insulin delivery , materials science , biomedical engineering , endocrinology , anesthesia , chemistry , chemical engineering , type 1 diabetes , organic chemistry , engineering
In article number 1800910 by Yu Shrike Zhang, Ai‐Zheng Chen, and co‐workers, insulin‐loaded poly‐ l ‐lactide porous microspheres (INS‐PLLA PMs) are fabricated by using supercritical fluid technology, serving as an inhalation delivery system potentially used towards diabetes therapy. The PLLA PMs show negligible toxicity to lung‐derived cells, and they are efficiently deposited in the trachea and the bronchi of the superior lobes of the lungs, which exhibit pronounced hypoglycemic activity in induced diabetic rats.