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Craniofacial Bone‐Tissue Engineering: Heparin‐Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF‐BB to Adipose‐Derived Stem Cells in Tissue Engineered Bone Grafts (Adv. Healthcare Mater. 10/2019)
Author(s) -
Rindone Alexandra N.,
Kachniarz Bartlomiej,
Achebe Chukwuebuka C.,
Riddle Ryan C.,
O'Sullivan Aine N.,
Dorafshar Amir H.,
Grayson Warren L.
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970042
Subject(s) - decellularization , materials science , biomedical engineering , stem cell , growth factor , tissue engineering , microbiology and biotechnology , adipose tissue , heparin , chemistry , medicine , biology , biochemistry , receptor
In article number 1801565 by Warren L. Grayson and co‐workers, a biomimetic growth factor delivery platform is developed to chemically conjugate heparin to osteoinductive, decellularized bone particles and allow for electrostatic tethering of platelet‐derived growth factor. Bone particles with tethered growth factor promote bone mineral deposition by adipose‐derived stem cells in vitro, and enhance bone formation mediated by these stem cells in vivo within murine critical‐sized calvarial defects.