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Cancer Immunotherapy: Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres (Adv. Healthcare Mater. 9/2019)
Author(s) -
Chen Lin,
Ma Xiaobo,
Dang Meng,
Dong Heng,
Hu Hongming,
Su Xiaodan,
Liu Wenfei,
Wang Qing,
Mou Yongbin,
Teng Zhaogang
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970041
Subject(s) - macrophage polarization , materials science , mesoporous material , immunotherapy , polarization (electrochemistry) , cancer immunotherapy , nanoparticle , iron oxide , macrophage , nanotechnology , immune system , catalysis , chemistry , medicine , immunology , biochemistry , in vitro , metallurgy
In article number 1900039 , Yongbin Mou, Zhaogang Teng, and co‐workers show that iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs) with core‐shell structure, high surface area, large mesopores and huge pore volume can initiate DC‐based T cell activation and tumor‐associated macrophage (TAM) polarization simultaneously. The combined T cell activation and macrophage polarization strategy based on the IO‐LPMONs elicits remarkable combined antitumor effects. This study demonstrates that the new‐synthesized IO‐LPMONs hold excellent potential as an immune modulator for cancerimmunotherapy.