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Oral Gene Delivery: NPC1L1‐Targeted Cholesterol‐Grafted Poly(β‐Amino Ester)/pDNA Complexes for Oral Gene Delivery (Adv. Healthcare Mater. 8/2019)
Author(s) -
Liu Yuan,
Chen Dan,
Li Jialin,
Xia Dengning,
Yu Miaorong,
Tao Jinsong,
Zhang Xinxin,
Li Li,
Gan Yong
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970032
Subject(s) - gene delivery , cytotoxicity , plasmid , transfection , gene , genetic enhancement , dna , cholesterol , chemistry , biochemistry , in vitro
In article number 1800934 , Yong Gan and co‐workers synthesize a cholesterol‐grafted poly ( β ‐amino ester) (CH‐PHP), which can electrostatically interact with plasmid DNA to form a CH‐PHP/DNA complex (CPNC) with mitigated cytotoxicity, enhanced enzyme resistance, and improved gene condensing ability. This complex can target the Niemann‐Pick C1‐like (NPC1L1) receptor, localized on the apical membrane of intestinal epithelia cells, to improve oral gene delivery efficacy.