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Endometrium Injury: PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus (Adv. Healthcare Mater. 5/2019)
Author(s) -
Xiao Bang,
Yang Wenjun,
Lei Dong,
Huang Jinfeng,
Yin Yupeng,
Zhu Yiqing,
You Zhengwei,
Wang Fang,
Sun Shuhan
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970018
Subject(s) - stromal cell , mesenchymal stem cell , uterus , stem cell , endometrium , in vivo , bone marrow , medicine , microbiology and biotechnology , biomedical engineering , pathology , biology
In article number 1801455 by Zhengwei You, Fang Wang, Shuhan Sun and co‐workers, PGS scaffolds show a modulus similar to that of native rat uterus tissue, while PLGA scaffolds and collagen are much stiffer. PGS scaffolds can significantly prolong the retention of the BMSCs in the injured uterus of rat models. More importantly, BMSCs in the constructs can directly differentiate into endometrial stromal cells. Finally, PGS/BMSCs significantly promote the morphologic and functional recovery of the injured rat uterus with recovered pregnancy rates up to 72.2 ± 6.4%, comparable to state‐of‐the‐art methods.