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Hypoxia: Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model (Adv. Healthcare Mater. 5/2019)
Author(s) -
Ando Yuta,
Siegler Elizabeth L.,
Ta Hoang P.,
Cinay Gunce E.,
Zhou Hao,
Gorrell Kimberly A.,
Au Hannah,
Jarvis Bethany M.,
Wang Pin,
Shen Keyue
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970015
Subject(s) - hypoxia (environmental) , chimeric antigen receptor , tumor microenvironment , infiltration (hvac) , cancer research , solid tumor , tumor cells , tumor hypoxia , cytotoxicity , cell , medicine , in vitro , materials science , immunotherapy , immunology , chemistry , oxygen , immune system , radiation therapy , cancer , biochemistry , organic chemistry , composite material
Hypoxia is a feature of most solid tumor microenvironments. Chimeric antigen receptor T (CAR‐T) cell therapy has not been successful in solid tumors, partially due to the tumor microenvironment. In article number 1900001 by Keyue Shen and co‐workers, an in vitro hypoxic tumor model with an oxygen gradient is engineered, which allows for quantitative assessment of CAR‐T cell cytotoxicity and infiltration under the heterogeneous oxygen landscape in solid tumors.