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Immunomodulation: Immunostimulatory Effects Triggered by Self‐Assembled Microspheres with Tandem Repeats of Polymerized RNA Strands (Adv. Healthcare Mater. 4/2019)
Author(s) -
Kim Dajeong,
Kim Hyejin,
Han Sangwoo,
Scatena Marta,
Kim DeokHo,
Lee Jong Bum
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201970011
Subject(s) - microsphere , polymerization , rna , materials science , nanotechnology , chemistry , polymer , chemical engineering , biochemistry , gene , engineering , composite material
In article number 1801395 , Deok‐Ho Kim, Jong Bum Lee, and co‐workers demonstrate immunostimulatory effects of RNA microspheres (RMSs), which are generated with single or double strands by rolling circle transcripton. Unlike the nature of RNA fragments, RMSs induce only basal‐level expression of inflammatory cytokines as well as type I interferon from macrophages, suggesting that RMSs are immunocompatible in the therapeutic dose range, while a systematic release increasing RNA fragments from RMSs could provide self‐assembled RNA‐based structures with a great potential for immunomodulation.