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Scaffold‐Free Bio‐3D Printing Using Spheroids as “Bio‐Inks” for Tissue (Re‐)Construction and Drug Response Tests
Author(s) -
Murata Daiki,
Arai Kenichi,
Nakayama Koichi
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901831
Subject(s) - scaffold , 3d printing , spheroid , 3d printer , 3d printed , tissue engineering , nanotechnology , 3d cell culture , materials science , biomedical engineering , computer science , cell , cell culture , chemistry , engineering , mechanical engineering , biology , composite material , biochemistry , genetics
In recent years, scaffold‐free bio‐3D printing using cell aggregates (spheroids) as “bio‐inks” has attracted increasing attention as a method for 3D cell construction. Bio‐3D printing uses a technique called the Kenzan method, wherein spheroids are placed one‐by‐one in a microneedle array (the “Kenzan”) using a bio‐3D printer. The bio‐3D printer is a machine that was developed to perform bio‐3D printing automatically. Recently, it has been reported that cell constructs can be produced by a bio‐3D printer using spheroids composed of many types of cells and that this can contribute to tissue (re‐)construction. This progress report summarizes the production and effectiveness of various cell constructs prepared using bio‐3D printers. It also considers the future issues and prospects of various cell constructs obtained by using this method for further development of scaffold‐free 3D cell constructions.