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Glutathione‐Depleting Nanoenzyme and Glucose Oxidase Combination for Hypoxia Modulation and Radiotherapy Enhancement
Author(s) -
Lyu Meng,
Zhu Daoming,
Kong Xiangyue,
Yang Yang,
Ding Shuaijie,
Zhou Yunfeng,
Quan Hong,
Duo Yanhong,
Bao Zhirong
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901819
Subject(s) - glutathione , glucose oxidase , biocompatibility , radiation therapy , hypoxia (environmental) , biophysics , chemistry , intracellular , materials science , extracellular , enzyme , oxygen , biochemistry , medicine , biology , organic chemistry
Nanoenzymes perceive the properties of enzyme‐like catalytic activity, thereby offering significant cancer therapy potential. In this study, Fe 3 O 4 @MnO 2 , a magnetic field (MF) targeting nanoenzyme with a core‐shell structure, is synthesized and applied to radiation enhancement with using glucose oxidase (GOX) for combination therapy. The glucose is oxidized by the GOX to produce excess H 2 O 2 in an acidic extracellular microenvironment, following which the MnO 2 shell reacts with H 2 O 2 to generate O 2 and overcome hypoxia. Concurrently, intracellular glutathione (GSH)—which limits the effects of radiotherapy (RT)—can be oxidized by the MnO 2 shell while the latter is reduced to Mn 2+ for T 1 ‐weighed MRI. The core Fe 3 O 4 , with its good magnetic targeting ability, can be utilized for T 2 ‐weighed MRI. In summary, the work demonstrates that Fe 3 O 4 @MnO 2 , as a dual T 1 ‐ and T 2 ‐weighed MRI contrast agent with strong biocompatibility, exhibits striking potential for radiation enhancement under magnetic targeting.