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Dynamic Bioinks to Advance Bioprinting
Author(s) -
Morgan Francis L. C.,
Moroni Lorenzo,
Baker Matthew B.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901798
Subject(s) - self healing hydrogels , computer science , dynamic covalent chemistry , 3d bioprinting , cell function , nanotechnology , tissue engineering , supramolecular chemistry , biochemical engineering , systems engineering , materials science , engineering , biomedical engineering , cell , chemistry , biochemistry , crystal structure , crystallography , polymer chemistry
The development of bioinks for bioprinting of cell‐laden constructs remains a challenge for tissue engineering, despite vigorous investigation. Hydrogels to be used as bioinks must fulfill a demanding list of requirements, mainly focused around printability and cell function. Recent advances in the use of supramolecular and dynamic covalent chemistry (DCvC) provide paths forward to develop bioinks. These dynamic hydrogels enable tailorability, higher printing performance, and the creation of more life‐like environments for ultimate tissue maturation. This review focuses on the exploration and benefits of dynamically cross‐linked bioinks for bioprinting, highlighting recent advances, benefits, and challenges in this emerging area. By incorporating internal dynamics, many benefits can be imparted to the material, providing design elements for next generation bioinks.