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Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering
Author(s) -
Qu Moyuan,
Jiang Xing,
Zhou Xingwu,
Wang Canran,
Wu Qingzhi,
Ren Li,
Zhu Jixiang,
Zhu Songsong,
Tebon Peyton,
Sun Wujin,
Khademhosseini Ali
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901714
Subject(s) - tissue engineering , regeneration (biology) , stem cell , cartilage , regenerative medicine , biomedical engineering , medicine , biology , microbiology and biotechnology , anatomy
Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.