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A Needle‐Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue
Author(s) -
Lee Seungmin,
Kim Jinyoung,
Kim Junyoung,
Hoshiar Ali Kafash,
Park Jongeon,
Lee Sunkey,
Kim Jonghyun,
Pané Salvador,
Nelson Bradley J.,
Choi Hongsoo
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901697
Subject(s) - drug delivery , materials science , fluidics , biomedical engineering , nanotechnology , drug , targeted drug delivery , paclitaxel , pharmacology , medicine , engineering , surgery , chemotherapy , aerospace engineering
A needle‐type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO 2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s −1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel‐loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle‐type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.