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Prototypic Heptamethine Cyanine Incorporating Nanomaterials for Cancer Phototheragnostic
Author(s) -
Leitão Miguel M.,
de MeloDiogo Duarte,
Alves Cátia G.,
LimaSousa Rita,
Correia Ilídio J.
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901665
Subject(s) - cyanine , nanomaterials , photothermal therapy , photodynamic therapy , nanotechnology , context (archaeology) , materials science , photoacoustic imaging in biomedicine , fluorescence , chemistry , optics , physics , paleontology , organic chemistry , biology
Developing technologies that allow the simultaneous diagnosis and treatment of cancer (theragnostic) has been the quest of numerous interdisciplinary research teams. In this context, nanomaterials incorporating prototypic near infrared (NIR)‐light responsive heptamethine cyanines have been showing very promising results for cancer theragnostic. The precisely engineered features of these nanomaterials endow them with the ability to achieve a high tumor accumulation, enabling a tumor's visualization by NIR fluorescence and photoacoustic imaging modalities. Upon interaction with NIR light, the tumor‐homed heptamethine cyanine‐incorporating nanomaterials can also produce a photothermal/photodynamic effect with a high spatio‐temporal resolution and minimal side effects, leading to an improved therapeutic outcome. This progress report analyses the application of nanomaterials incorporating prototypic NIR‐light responsive heptamethine cyanines (IR775, IR780, IR783, IR797, IR806, IR808, IR820, IR825, IRDye 800CW, and Cypate) for cancer photothermal therapy, photodynamic therapy, and imaging. Overall, the continuous development of nanomaterials incorporating the prototypic NIR absorbing heptamethine cyanines will cement their phototheragnostic capabilities.