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Plasmonic Copper Sulfide Nanoparticles Enable Dark Contrast in Optical Coherence Tomography
Author(s) -
Marin Riccardo,
Lifante José,
Besteiro Lucas V.,
Wang Zhiming,
Govorov Alexander O.,
Rivero Fernando,
Alfonso Fernando,
SanzRodríguez Francisco,
Jaque Daniel
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901627
Subject(s) - plasmon , optical coherence tomography , nanoparticle , materials science , plasmonic nanoparticles , nanotechnology , contrast (vision) , copper sulfide , transparency (behavior) , optics , optoelectronics , copper , computer science , physics , computer security , metallurgy
Optical coherence tomography (OCT) is an imaging technique affording noninvasive optical biopsies. Like for other imaging techniques, the use of dedicated contrast agents helps better discerning biological features of interest during the clinical practice. Although bright OCT contrast agents have been developed, no dark counterpart has been proposed yet. Herein, plasmonic copper sulfide nanoparticles as the first OCT dark contrast agents working in the second optical transparency window are reported. These nanoparticles virtually possess no light scattering capabilities at the OCT working wavelength (≈1300 nm); thus, they exclusively absorb the probing light, which in turn results in dark contrast. The small size of the nanoparticles and the absence of apparent cytotoxicity support the amenability of this system to biomedical applications. Importantly, in the pursuit of systems apt to yield OCT dark contrast, a library of copper sulfide nanoparticles featuring plasmonic resonances spanning the three optical transparency windows is prepared, thus highlighting the versatility and potential of these systems in light‐controlled biomedical applications.