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Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis
Author(s) -
Mu Zhixiang,
Chen Kaiwen,
Yuan Shuai,
Li Yihan,
Huang Yuanding,
Wang Chao,
Zhang Yang,
Liu Wenzhao,
Luo Wenping,
Liang Panpan,
Li Xiaodong,
Song Jinlin,
Ji Ping,
Cheng Fang,
Wang Huanan,
Chen Tao
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901469
Subject(s) - self healing hydrogels , gelatin , biomedical engineering , materials science , fibrin , regeneration (biology) , extracellular matrix , nanoparticle , platelet rich fibrin , nanotechnology , biophysics , chemistry , microbiology and biotechnology , biochemistry , medicine , immunology , polymer chemistry , biology
Abstract Bone healing is a dynamic process regulated by biochemical signals such as chemokines and growth factors, and biophysical signals such as topographical and mechanical features of extracellular matrix or mechanical stimuli. Hereby, a mechanically tough and bioactive hydrogel based on autologous injectable platelet‐rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) is developed. This composite hydrogel demonstrates a double network (DN) mechanism, wherein covalent network of fibrin serves to maintain material integrity, and self‐assembled colloidal network of GNPs dissipates force upon loading. A rabbit sinus augmentation model is used to investigate the bioactivity and osteogenesis capacity of the DN hydrogels. The DN hydrogels adapt to the local environmental complexity of bone defects, i.e., accommodate the irregular shape of the defects and withstand the pressure formed in the maxillary sinus during animal's respiration process. The DN hydrogel is also demonstrated to absorb and prolong the release of the bioactive growth factors stemming from iPRF, which could have contributed to the early angiogenesis and osteogenesis observed inside the sinus. This adaptable and bioactive DN hydrogel can achieve enhanced bone regeneration in treating complex bone defects by maintaining long‐term bone mass and withstanding the functional mechanical stimuli.