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Peptidic Monodisperse PEG “Comb” as Multifunctional “Add‐On” Module for Imaging‐Traceable and Thermo‐Responsive Theranostics
Author(s) -
Zhu Junfei,
Zhang Huaibin,
Chen Kexin,
Li Yu,
Yang Zhigang,
Chen Shizhen,
Zheng Xing,
Zhou Xin,
Jiang ZhongXing
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901331
Subject(s) - biocompatibility , materials science , drug delivery , amphiphile , peg ratio , nanotechnology , liposome , pegylation , dispersity , fluorescence lifetime imaging microscopy , polyethylene glycol , fluorescence , biophysics , biomedical engineering , chemistry , copolymer , polymer , organic chemistry , polymer chemistry , medicine , finance , economics , physics , quantum mechanics , metallurgy , composite material , biology
Monodisperse polyethylene glycols–modified (M‐PEGylated) biomaterials exhibit high structural accuracy, biocompatibility, and fine‐tunable physicochemical properties. To develop “smart” drug delivery systems in a controllable and convenient manner, a peptidic M‐PEG “comb” with fluorinated L ‐lysine side chains and a fluorescent N ‐terminal is conveniently prepared as a 19 F magnetic resonance imaging ( 19 F MRI) and fluorescence dual‐imaging traceable and thermo‐responsive “add‐on” module for liposomal theranostics in cancer therapy. The peptidic M‐PEG “comb” has high biocompatibility, thermo‐responsivity with a sharp lower critical solution temperature, an aggregation‐induced emission fluorescence, and high 19 F MRI sensitivity. As a highly branched amphiphile, it self‐assembles and firmly anchors on the doxorubicin‐loaded liposomal nanoparticles, which M‐PEGylates the liposomes and facilitates the thermo‐responsive drug release and drug tracking with dual‐imaging technologies. In a rodent xenograft model of human liver cancer HepG2 cells, the M‐PEGylated liposomes exhibit long in vivo half time, low toxicity, high tumor accumulation, “hot spot” 19 F MRI, and therapeutic efficacy. With accurately programmable chemical structure, fine‐tunable physicochemical and biological properties to meet the demands of diagnosis, drug delivery, and therapy, the M‐PEG “comb” is promising as a versatile “add‐on” module for rapid and convenient formulation of various “smart” theranostics.