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An Oxygen Self‐Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment
Author(s) -
Jiang Wei,
Han Xiaoxue,
Zhang Taixing,
Xie Diya,
Zhang Hao,
Hu Yong
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901303
Subject(s) - internalization , hypoxia (environmental) , tumor hypoxia , tumor microenvironment , in vivo , penetration (warfare) , nanoparticle , photothermal therapy , cancer cell , in vitro , cancer research , radiation therapy , biophysics , oxygen delivery , tumor cells , oxygen , chemistry , cancer , materials science , nanotechnology , medicine , cell , biology , biochemistry , microbiology and biotechnology , organic chemistry , operations research , engineering
The hypoxia‐induced resistance to radiotherapy (RT) is a great threat to cancer patients. Therefore, overcoming the hypoxia tumor microenvironment is a vital issue. Herein, spindle‐shaped CuS@CeO 2 core–shell nanoparticles combining self‐supplied oxygen, photothermal ability, and RT sensitive to cancer therapy are introduced. The spindle shape of CuS@CeO 2 core–shell nanoparticles can potentiate their tumor penetration and subsequent internalization by cancer cells. The presence of CeO 2 , functioning as a nanoenzyme, catalyzes the endogenous H 2 O 2 in tumor tissue into O 2 , which remodels the hypoxic microenvironment into one susceptible to RT. CuS nanoparticles encapsulated in CeO 2 undergo a steady release and deep tumor penetration, allowing the regression of lesions less affected by RT. Furthermore, in vitro and in vivo studies reveal that the design not only mitigates the dosage of RT, but more importantly allows the entire tumor to be treated without relapses.