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Probing the Impedance of a Biological Tissue with PEDOT:PSS‐Coated Metal Electrodes: Effect of Electrode Size on Sensing Efficiency
Author(s) -
Koutsouras Dimitrios A.,
Lingstedt Leona V.,
Lieberth Katharina,
Reinholz Jonas,
Mailänder Volker,
Blom Paul W. M.,
Gkoupidenis Paschalis
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901215
Subject(s) - pedot:pss , materials science , polystyrene sulfonate , electrode , electrical impedance , dielectric spectroscopy , biosensor , optoelectronics , polystyrene , sensitivity (control systems) , biomedical engineering , nanotechnology , electronic engineering , polymer , composite material , chemistry , electrical engineering , medicine , electrochemistry , engineering
Electrodes coated with poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have been employed to measure the integrity of cellular barriers. However, a systematic experimental study of the correlation between tissue integrity and impedance of the sensing device has not yet been conducted. Using impedance spectroscopy, how the impedance ratio of the biological tissue to the recording device affects the recording ability of the latter is investigated. PEDOT:PSS‐coated electrodes of various dimensions are employed and the effect of their size to their sensing efficiency is examined. The biotic/abiotic ensemble is modeled with a simple equivalent circuit and an analytical expression of the total impedance as a function of frequency is extracted. The results reveal a critical impedance ratio of the biological tissue to the sensor which allows for efficient sensing of the tissue integrity. This work provides the ground rules for improved impedance‐based biosensors with optimized sensitivity.