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Bioinspired Biomaterials with a Brick‐and‐Mortar Microstructure Combining Mechanical and Biological Performance
Author(s) -
Li Tian,
Ma Bing,
Xue Jianmin,
Zhai Dong,
Zhao Pengyu,
Chang Jiang,
Wu Chengtie
Publication year - 2020
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901211
Subject(s) - bioceramic , materials science , lamellar structure , biomaterial , microstructure , biomedical engineering , mortar , composite material , nanotechnology , medicine
The fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity, remains challenging because these properties are usually mutually exclusive. Herein, inspired by the brick‐and‐mortar architecture of nacre, lamellar silicate‐based bioceramic composites are successfully prepared by constructing orderly layered bioceramics infiltrated with a biomedical resin interlayer via the bidirectional freezing technique. The lamellar composites possess high strength and proper Young's moduli, which match with human cortical bone. Furthermore, the lamellar composites can release bioactive ions with a controlled profile, which significantly enhance the cell proliferation of both rabbit bone mesenchymal stem cells and periodontal ligament cells in vitro. Moreover, with the degradation of silicate bioceramics in vivo, newly formed bone tissue can grow into the materials to present the bioceramic/new bone/resin sandwich‐like lamellar microstructure. The silicate‐based bioceramic composites with brick‐and‐mortar architecture represent an excellent biomaterial in combination of superior mechanical performances matching that of human cortical bone, and excellent bioactivity for potential load‐bearing bone regeneration.