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3D Printed Microheater Sensor‐Integrated, Drug‐Encapsulated Microneedle Patch System for Pain Management
Author(s) -
Yin Mengtian,
Xiao Li,
Liu Qingchang,
Kwon SungYun,
Zhang Yi,
Sharma Poonam R.,
Jin Li,
Li Xudong,
Xu Baoxing
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201901170
Subject(s) - microheater , materials science , polydimethylsiloxane , transdermal , nanotechnology , drug delivery , 3d printed , electronics , transdermal patch , biomedical engineering , wearable technology , inkwell , printed electronics , wearable computer , computer science , composite material , embedded system , medicine , fabrication , electrical engineering , alternative medicine , engineering , pathology , pharmacology
Microneedle patch devices have been widely utilized for transdermal drug delivery in pain management, but is challenged by accurate control of drug release and subsequent diffusion to human body. The recent emerging wearable electronics that could be integrated with microneedle devices offer a facile approach to address such a challenge. Here a 3D‐printed microheater integrated drug‐encapsulated microneedle patch system for drug delivery is presented. The ink solution comprised polydimethylsiloxane (PDMS) and multiwalled carbon nanotubes (MWCNTs) with a mass concentration of up to 45% (≈10 times higher of existing ones) is prepared and used to print crack‐free stretchable microheaters on substrates with a broad range of materials and geometric curves. The adhesion strength of the printed microheater on the microneedle patch in elevated temperatures is measured to evaluate their integration performance. Assessments of encapsulated drug release into rat's skin are confirmed by examining degradation of microneedles, skin morphologies, and released fluorescent signals. Results and demonstrations established here creates a new opportunity for developing sensor controlled smart microneedle patch systems by integrating with wearable electronics, potentially useful in clinical and biomedical research.