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5‐Aminolevulinic Acid‐Loaded Hyaluronic Acid Dissolving Microneedles for Effective Photodynamic Therapy of Superficial Tumors with Enhanced Long‐Term Stability
Author(s) -
Zhu Jinjin,
Dong Liyun,
Du Hongyao,
Mao Jinzhu,
Xie Ying,
Wang Hua,
Lan Jiajia,
Lou Yuchen,
Fu Yangxue,
Wen Jingjing,
Jiang Biling,
Li Yuce,
Zhu Jintao,
Tao Juan
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900896
Subject(s) - photodynamic therapy , in vivo , stratum corneum , hyaluronic acid , prodrug , materials science , penetration (warfare) , chemistry , biomedical engineering , organic chemistry , biochemistry , medicine , pathology , microbiology and biotechnology , anatomy , operations research , engineering , biology
Abstract 5‐Aminolevulinic acid (5‐ALA) is one of the most widely used prodrug in clinical photodynamic therapy of dermatological diseases and cancers; yet, its clinical application is still limited by the shallow skin penetration and unsatisfied stability in any existed formulations. Here, 5‐ALA‐loaded hyaluronic acid dissolving microneedles (5‐ALA@HAMNs) are prepared for photodynamic therapy of superficial tumors. The HAMNs can not only assist the loaded 5‐ALA to effectively penetrate the stratum corneum but also provide 5‐ALA with an acidic and oxygen‐free environment to reduce the dimerization of 5‐ALA molecules via Schiff‐base bonds and formation of inactive pyrazine derivatives, thus maintaining its chemical structure and biological activity. The chemical stability of 5‐ALA in HAMNs is confirmed by UV–vis spectra and mass spectra measurements. The 5‐ALA@HAMNs display remarkable tumor elimination both in vitro and in vivo, even after storage at room temperature for nine months, making it a highly potential device for effective delivery of 5‐ALA in cancer photodynamic therapy.