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Magnetically Actuated SiCN‐Based Ceramic Microrobot for Guided Cell Delivery
Author(s) -
Gyak KiWon,
Jeon Sungwoong,
Ha Laura,
Kim Sangwon,
Kim Jinyoung,
Lee KwangSup,
Choi Hongsoo,
Kim DongPyo
Publication year - 2019
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201900739
Subject(s) - materials science , ceramic , nanoparticle , inert , polymer , nanotechnology , composite material , biocompatible material , lithography , silicon , optoelectronics , biomedical engineering , medicine , physics , quantum mechanics
A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface‐modified ceramic carrier by thiol‐ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.